Hon Ssemujju holds a career in journalism, a reporter for the Daily Monitor, one of the two leading English language daily newspapers in Uganda, he served in that role until 2004, he was a political editor at the Weekly Observer, serving in that role until 2011. He taught journalism at the Islamic University in Uganda. Prior to the February 2016 presidential, parliamentary, and local elections, in Kira Municipality he was awarded a parliamentary seat, separate from Kyaddondo East. In parliament, he chairs the Committee on Commissions, Statutory Authorities and State Enterprises. He is also a member of the Committee on Defence and Internal Affairs and of the Business Committee